Stevens-Johnson syndrome is a potential adverse reaction to which antiseizure medication?

• A. Phenytoin
• B. Valproic acid
• C. Gabapentin
• D. Diazepam

Answer: (A)

Stevens-Johnson syndrome is a severe, immune-mediated reaction that can occur with certain anticonvulsants. Among common antiseizure medicines, phenytoin has a well-known association with this dangerous reaction, especially early after starting treatment or after dose changes. The other drugs listed are not typically linked to Stevens-Johnson syndrome; valproic acid more often causes hepatotoxicity and other issues, while gabapentin and diazepam have much lower risks for this specific reaction. Therefore, phenytoin is the best choice when considering which antiseizure medication can be associated with Stevens-Johnson syndrome. If such a reaction is suspected, stop the drug immediately and seek urgent medical care.