What drug is used to help reduce the EPS side effects?

Study for the Galen Pharmacology Exam 1 Test. Use flashcards and multiple choice questions with hints and explanations. Achieve exam success!

Multiple Choice

What drug is used to help reduce the EPS side effects?

Explanation:
Extrapyramidal symptoms come from blocking dopamine in the nigrostriatal pathway, which lets acetylcholine activity become relatively dominant and produces parkinsonian-like signs and dystonia. Benztropine is an anticholinergic that blocks muscarinic receptors, reducing acetylcholine activity in that pathway and thereby alleviating EPS such as tremor, rigidity, and dystonia. That makes it the best choice to counter these side effects. In contrast, increasing dopamine with L-DOPA (or Levodopa) would worsen EPS by boosting dopaminergic signaling. Fluvoxamine is an SSRI and does not address the dopaminergic–cholinergic imbalance underlying EPS, so it isn’t used for this purpose.

Extrapyramidal symptoms come from blocking dopamine in the nigrostriatal pathway, which lets acetylcholine activity become relatively dominant and produces parkinsonian-like signs and dystonia. Benztropine is an anticholinergic that blocks muscarinic receptors, reducing acetylcholine activity in that pathway and thereby alleviating EPS such as tremor, rigidity, and dystonia. That makes it the best choice to counter these side effects.

In contrast, increasing dopamine with L-DOPA (or Levodopa) would worsen EPS by boosting dopaminergic signaling. Fluvoxamine is an SSRI and does not address the dopaminergic–cholinergic imbalance underlying EPS, so it isn’t used for this purpose.

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