Which SSRI is commonly used and widely known?

• A. Sertraline
• B. Paroxetine
• C. Citalopram
• D. Fluoxetine

Answer: (D)

SSRIs work by increasing serotonin in the brain by blocking its reuptake. Fluoxetine stands out as the most commonly used and widely known among them because it has a long history of use, is familiar to most clinicians, and is approved for multiple conditions (depression, obsessive-compulsive disorder, bulimia nervosa, panic disorder, and more). Its pharmacokinetic profile features a long half-life and an active metabolite, which allows for once-daily dosing and reduces withdrawal symptoms, helping it stay at the top of both prescriber and patient familiarity. This combination of broad indications, enduring presence in practice, and easier adherence makes fluoxetine the standout choice. Other SSRIs are also widely used, but fluoxetine’s brand recognition and long-standing track record make it the most commonly known.